Abstract Library

#2705 Increased Autophagy/Mitophagy Levels in Pancreatic Neuroendocrine Neoplasms

Introduction: Autophagy and mitophagy are key homeostatic machineries linked to cancer development and drug resistance.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author:

Authors: Daskalakis K, Alexandraki K, Kloukina I, Kassi E, Felekouras E,

Keywords: Pancreatic Neuroendocrine Tumors, Autophagy, Mitophagy,

#2682 PAK4-NAMPT Dual Inhibition as a Novel Strategy for Therapy Resistant Pancreatic Neuroendocrine Tumors

Introduction: Pancreatic neuroendocrine tumors (PNET) remain an unmet clinical need. In this study, we show that targeting both nicotinamide phosphoribosyltransferase (NAMPT) and p21-activated kinase 4 (PAK4) could become a synthetic lethal strategy for PNET.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Mpilla G

Authors: Mpilla G, Aboukameel A, Muqbil I, Kim S, Philip P,

Keywords: pak4, nampt, mtor, pancreatic neuroendocrine tumors, kpt-9274,

#2091 Differential Signalling Pathways Drive Therapeutic Resistance in Neuroendocrine Tumors

Introduction: Most of the current therapeutic strategies used for neuroendocrine tumors (NETs) are insufficient due to poor knowledge of these tumours. Despite showing differentiated features, NETs often exhibit therapeutic resistance to common treatments similarly to other cancers. Although signalling abnormalities have been reported, molecular mechanisms responsible for this resistance phenomenon are yet to be understood.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author:

Authors: Romano D, Gerard C, Poizat F, Niccoli P, Barlier A,

Keywords: neuroendocrine tumors, drug resistance, proteomics, kinases, apoptosis,

#1739 A Kinomic Approach to Identify Signaling Proteins Involved in Drug Resistance in GastroEnteroPancreatic Neuroendocrine Tumors

Introduction: Most of the current therapeutic strategies used for neuroendocrine tumors (NETs) result in tumour growth stabilization, eventually followed by tumour progression. Thus, despite their original characteristics, NETs exhibit similar resistance features to treatments than other more common tumours.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author: Romano D

Authors: Romano D, Gerard C, Mondielli G, Lisbonis C, Niccoli P,

Keywords: Neuroendocrine Tumors, Drug resistance, Proteomics, Kinases,